“I am going back on the air Monday, March 30th. All my staff will work from home, I will shoot at home using an iPhone, and my guests will Skype,” the TV host, 56, tweeted on Thursday.

He added, “This will not be pretty, but feel free to laugh at our attempt.”

O’Brien also urged fans to “stay safe,” amid the outbreak.

With the spread of the coronavirus pandemic, several other talk show hosts have discontinued filming in the studio and have instead opted to put on shows in isolation.

Whoopi Goldberg co-hosted “The View” while she self-isolates at her home, taking extra precaution after contracting double pneumonia last year.

Likewise, Jimmy Fallon has been hosting “The Tonight Show” from his home with the help of his wife Nancy Juvonen as cameraman and his adorable daughters making guest appearances.

Savannah Guthrie has taken to co-hosting the “Today” show from her basement as she self-quarantined.

Dr. Oz has also started filming remotely after a staffer tested positive for coronavirus.

Meanwhile, otther shows have shut down completely including this year’s “American Idol.”