“I definitely re-watched [the 1993 film],” Holbrook, 38, tells The Post. “I also watched the original TV show, which the film was based on. I just wanted to have the full essence, because there’s a 30-year gap between those two. It was interesting to have some reference.

“But this story was so radically different there was nothing to compare it to.”

In the series, streaming on mobile platform Quibi, Holbrook plays Mike Ferro, who’s wanted for planting a bomb on an LA subway train, leaving dozens dead. He tries to prove his innocence while protecting his wife (Natalie Martinez, “The Crossing”) and their 10-year-old daughter (Keilani Arellanes).

Kiefer Sutherland plays Clay Bryce, the cop hunting Ferro down. The role was originated by Barry Morse (Lt. Gerard) in the original ABC series starring David Janssen; Tommy Lee Jones played Deputy US Marshal Samuel Gerard in the movie.

“[Harrison Ford] was a doctor and Mike Ferro is sort of an average, everyday, blue-collar guy,” says Holbrook. “It’s two different scenarios. Here, it’s also about just how hard it is to get a job if you’re a felon, and how difficult it is to reverse your reflection in society. The context is different, but it’s playing off that theme that’s so classic.”

Holbrook says that he didn’t try to model his performance on the 1993 movie, but remembers watching it as a kid growing up in Kentucky.

“It was probably one of the first times I saw a film in a movie theater. And it was epic, it was awesome, a really cutting- edge story,” he says. “In terms of trying to fill the shoes of [Ford], that’s not really my interest. It’s about leaving your own footprint and the essence of [the role] as an innocent man on the run.

“I wouldn’t be too surprised if the next ‘Fugitive’ has a female in the lead.”

Ferro spends most of the series trying to evade the authorities, so Holbrook says he didn’t spend much time on the set with Sutherland.

“I only got to work with him for two days,” he says. “But it was amazing to see how focused he is and how ‘on’ he is for the job. It’s good to know that Kiefer is on your side.”

Holbrook is best-known for playing Steve Murphy for two seasons on “Narcos” and as the stylish villain Donald Pierce opposite Hugh Jackman in “Logan.” He’s based in New York with his wife, Danish actress Tatiana Pajkovi, and their young son, and has several high-profile projects on the horizon.

He’s in “Platform,” a TV show created by “The Office” star B.J. Novak; the action flick “Born to be Murdered,” opposite Alicia Vikander; and another Novak project, a thriller called “Vengeance,” co-starring Issa Rae and Ashton Kutcher.

“We were just shooting [Novak’s] first feature film out in Albuquerque when all this happened, so we’re kind of stalled out,” he says about the pandemic shutdown. “We’re hoping to go back to work. If you asked me in drama school if I’d ever do a kids movie, I would have laughed at that, but last year I worked with Robert Rodriguez on a kids’ film [‘We Can Be Heroes’].

“I really like trying different things and working with different people that excite me,” he says, “and getting up and going to work to make something that somebody can enjoy.”